Sc(OTf)3-Catalyzed Diastereoselective [3 + 3] Cycloaddition of Chiral Bicyclo[1.1.0]butanyl Imides and Nitrones
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A chiral-auxiliary-induced asymmetric synthesis of 2-oxa-3-azabicyclo[3.1.1]heptanes is described. This approach employs a new class of chiral bicyclo[1.1.0]butanes incorporating an (S)-4-benzyl-2-oxazolidinone auxiliary as the key chiral controller. The Sc(OT... ...
