Bifunctional 2-Aminopyridine-Catalyzed Aza-Friedel-Crafts/Oxa-6π Cascade: Synthesis of 2,2-Disubstituted Chromenes
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In this study, we present an efficient organocatalytic one-pot strategy for the synthesis of 2-gem-dialkyl/aryl chromenes using a bifunctional 2-aminopyridine catalyst. The reaction employs inexpensive phenols and β,β-disubstituted enals and proceeds through... ...
