Tandem 1,3-Dipolar Cycloaddition/Rearrangement of Nitronates with Cyclooctyne for the Diastereoselective Synthesis of Spiroaziridine Derivatives
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The 1,3-dipolar cycloaddition of cyclic nitronates (5,6-dihydro-4H-1,2-oxazine N-oxides) with cyclooctyne affords oxazine-annulated spiroaziridine derivatives in mild conditions with high yields and diastereoselectivity via consecutive strain-promoted [3 + 2]-... ...
