1H, 13C, and 15N backbone resonance assignments of the A2 domain of human von Willebrand factor
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The A2 domain of von Willebrand factor (vWF A2) acts as a mechanosensor, unfolding under shear stress to enable cleavage by ADAMTS13. Dysfunction of this process causes von Willebrand disease (VWD) and thrombotic thrombocytopenic purpura (TTP). Although we pre... ...
