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Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC Enterococcus faecium natural isolate

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Enterococcus faecium exhibits intrinsic resistance to cephalosporins (CPHs), yet the genetic determinants of this phenotype remain incompletely understood. To date, E. faecium strains with low minimum inhibitory concentrations (MICs) of CPH have only been desc... ...