Bi-Target Nanomodulator for Glioma-Associated Myeloid Cells Polarization by Inducing Pyroptosis and Regulating Tryptophan Metabolism to Reshape Immunosuppressive Microenvironment of IDH-Mutant Gliomas
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Since 2-hydroxyglutarate (2-HG) released from isocitrate dehydrogenase (IDH)-mutant gliomas results in the strong immunosuppressive tumor microenvironment (TME), the immunotherapy effect is unsatisfactory. In this work, we develop a hybridized cell membrane of... ...
