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Preformed HNA-3a antibodies in renal transplantation: A suggested approach to risk assessment

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Patients presenting with a homozygous human neutrophil antigen-3b (HNA-3b)/3b genotype are at risk of HNA-3a alloimmunisation, generating anti-HNA-3a antibodies, which are known to cause severe transfusion-related acute lung injury (TRALI). HNA-3b homozygosity... ...