Lysosomal down-regulation of the mu opioid receptor is opposed by the Retromer complex
{{output}}
A critical homeostatic mechanism for regulating G protein-coupled receptor (GPCR) activity is agonist-induced GPCR endocytosis and trafficking to the lysosome for proteolytic down-regulation. The mu opioid receptor (MOR) is a notable example of this type of ce... ...
