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Differential effects of non-selective and cardio-selective beta-blocker therapy on ECG parameters in long QT syndrome type 1

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•Non-selective β-blockers markedly reduce Tpeak/end in LQT1 patients.•Cardio-selective β-blockers show no consistent effect on Tpeak/end.•The nsBB effect persists after exercise, independent of heart rate.•Tpeak/end shortening indicates decreased global ... ...