Integrated Multi-Omics Analysis Elucidates the Metabolic Basis of Enhanced Echinocandin B Biosynthesis and Guides Targeted Engineering in Aspergillus nidulans
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Echinocandin B (ECB) serves as a crucial precursor for the antifungal drug anidulafungin, yet its production cost remains high due to low fermentation titers. We previously screened a highly efficient ECB producer Aspergillus nidulans ZJB16068, but its further... ...
