PKC isoform-specific targeting of the phosphorylation site Serine191 in the GIRK4 subunit induces receptor-dependent modulation of GIRK channel activity
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G Protein activated inwardly rectifying K+ (GIRK) channels are inhibited during stimulation of Gq Protein-coupled receptors (GqPCRs) by depletion of phosphatidyl-4,5-bisphosphate (PIP2) and/or channel phosphorylation by proteinkinase C (PKC). Receptor-specific... ...
