Repurposing flufenamic acid as a putative PmrB-directed adjuvant to restore colistin activity in Klebsiella pneumoniae
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Antimicrobial resistance in gram-negative bacteria has renewed reliance on colistin, yet resistance to this last-line agent is increasing. In Klebsiella pneumoniae, activation of the PmrA/PmrB two-component system remodels lipid A and reduces colistin binding,... ...
