AI-Based Prediction of PROTAC- and Molecular Glue-Mediated Ternary Complexes: A Comparative Evaluation of AlphaFold 3 and Boltz-2
{{output}}
Proteolysis targeting chimeras (PROTACs) and molecular glues induce ligand-mediated ternary complexes between an E3 ubiquitin ligase and a protein of interest, but their in silico modeling remains challenging due to conformational flexibility and weak protein-... ...
