Expanding repeats, expanding impact: Somatic instability in myotonic dystrophy type 1
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Myotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder caused by a CTG(n) repeat expansion in the 3'-untranslated region of the DMPK gene. The repeat tract becomes unstable when exceeding approximately 35 to 50 CTG triplets, expanding both ... ...
