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Practical Rh-ZhangPhos Catalyzed Asymmetric Hydrogenation of Enamides: From Scalable Access to Mechanistic Insight

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Herein, we report a simple, one-pot, scalable process for the preparation of a series of enamides, which were subsequently hydrogenated with high efficiency and excellent enantioselectivity to the corresponding chiral amides using the Rh-ZhangPhos catalyst. Th... ...