A spring-loaded grip-and-pull mechanism for stepwise RNA duplex unwinding by Xrn1
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Xrn1 is a highly conserved 5'→3' exoribonuclease that plays a central role in RNA turnover and quality control in eukaryotic cells. Although Xrn1 is known to degrade single-stranded RNA in a processive manner, the mechanism by which it engages and unwinds s... ...
