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High-throughput clone screening and upstream process optimization for recombinant therapeutic peptide expression: biosimilar teriparatide (PTH-34): a case study

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The study focuses on high-throughput optimization of the upstream process for the expression of biosimilar teriparatide using a microfermenter platform. Key upstream parameters, including E. coli host strains, growth media, and induction strategies, were syste... ...