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Expression, purification, and crystallization of recombinant human ABL-1 kinase for X-ray crystallography

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Abelson-1 (ABL-1) is a nonreceptor tyrosine kinase that plays essential roles in various cellular processes, including proliferation, survival, differentiation and its kinase activity is tightly regulated. The dysregulated ABL-1 kinase activity is linked to di... ...