LeiCNS-PK3.2: A Physiologically Based Pharmacokinetic Model Framework for Predicting intracellular Concentrations of Acyclovir and Ganciclovir Active Metabolites
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Background: Effective treatment of viral infections in the central nervous system (CNS) requires adequate nucleoside analogs exposure and conversion into phosphorylated metabolites (TP) in brain cells. ... ...
