Prognostic factors and outcome measures after BRAF-directed targeted therapy of unresectable metastatic BRAFV600E colorectal cancer: a study cohort-level analysis
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BRAFV600E mutation in metastatic colorectal cancer (mCRC) is associated with a poor prognosis. BRAFV600E inhibitors (BRAFi) plus EGFR inhibitors + / - MEK inhibitors regimens prolonged overall survival (OS), but prognosis remains heterogeneous and intermediate... ...