Influence of CYP2D6 phenotype on the pharmacokinetics and pharmacodynamics of tramadol in patients treated for post-operative pain management
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Introduction: Tramadol is widely used in post-operative pain management. Concentrations of tramadol and its active metabolite O-demethyl tramadol (O-dT) are influenced by cytochrome P450 2D6 (CYP2D6) genotype. ... ...
