The metabolome of an E. coli CRISPRi library identifies benefits of minimal metabolite levels and targets for engineering
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Metabolite concentration changes can have broad consequences on the function and robustness of metabolic networks. Here, we measured the metabolome response of 1,515 CRISPR interference (CRISPRi) E. coli strains targeting all genes in the iML1515 metabolic mod... ...
