A one-step, resin-compatible Cys-Trp cross-linking system opens a new avenue for stapled peptide therapeutics
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Protein-protein interactions (PPIs) are attractive yet challenging drug targets, motivating the development of conformationally constrained peptides such as stapled α-helices. Here we report a one-pot cysteine-tryptophan (Cys-Trp) cross-linking strategy that ... ...