Dnmt3a-dependent de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells
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Following acute viral infection, naive CD4+ T cells differentiate into T follicular helper (Tfh) and T helper 1 (Th1) cells that generate long-lived memory. However, it is unclear how memory Tfh and Th1 cells maintain their lineage commitment. We demonstrate t... ...
