Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous dsRNA
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Loss of the lariat debranching enzyme DBR1 causes cytoplasmic accumulation of intron lariats, but why this reduces cell-intrinsic immunity is unclear. Here, we show that intronic inverted repeats Alu (IR Alus), normally degraded after splicing, form long doubl... ...
