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T-cell epitope supplementation enhanced cross-protection against H7N9 AIV in chickens via upregulated HA epitope-specific T cell and CD4 T cell-mediated help

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The continuous circulation of H7N9 avian influenza viruses (AIVs) in poultry poses a significant public health threat. T cell-mediated immunity favors enhanced and broad protection against viruses. However, it remains challenging to exploit avian T-cell immuni... ...