Enhancing RNAi activity through 4'-O-hexadecyl-2'-deoxythymidine modification in the passenger strand
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Various lipid-based siRNA drug delivery strategies are being developed for efficient delivery to extrahepatic organs. In this report, we studied the synergistic effect of 4'-O-hexadecyl-2'-dT and terminal phosphorothioate modifications on siRNA duplex stabil... ...
