Heterologous production of epothilones in Streptomyces albus J1074 via promoter engineering of the biosynthetic gene cluster and precursor supply enhancement
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Epothilones, synthesized by hybrid polyketide synthases (PKS)-nonribosomal peptide synthetases (NRPS), are clinically valuable anti-cancer macrolides with potent activity against multidrug-resistant tumors. They are naturally produced by the myxobacterium Sora... ...
