The CDKL5 kinase undergoes liquid-liquid phase separation driven by a serine-rich C-terminal region
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The CDKL5 gene encodes a protein kinase involved in nervous system development and function. Pathogenic variants in this gene can cause a severe neurodevelopmental CDKL5 deficiency disorder (CDD). The CDKL5 protein contains a catalytic N-terminal domain (NTD) ... ...
