HAAC Ligation-Enabled Hierarchical Assembly: Deciphering the Synergy of α-Hydroxyl Aldehydes and 2-Aminooxazoles
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We report α-hydroxyl aldehyde-2-aminooxazole conjugation (HAAC), a bioorthogonal ligation platform that enables selective biomolecular labeling and functional modulation under physiological conditions (pH 7.0, 37 °C). HAAC chemistry supports: (1) multiplexed... ...
