Fragment merging design, synthesis, and biological evaluation of novel methyl Selanyl- And thiazolidinedione-based hybrids as potent anticancer inducing apoptosis and cell cycle arrest
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A novel series of methyl selanyl- and 2,4-thiazolidinedione-based hybrids (HB68-HB167) was rationally designed using a fragment-merging strategy, in which key pharmacophoric elements were combined to generate structurally integrated hybrid molecules with enhan... ...