Structural and morphological dynamics of "on-path" and "off-path" oligomers of human islet amyloid polypeptide
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The deposition of cytotoxic human islet amyloid polypeptide (IAPP) aggregates is a hallmark feature of Type 2 Diabetes. However, the structural evolution and cytotoxicity of IAPP aggregate species remain poorly understood. This study combines kinetics, biophys... ...
