Structure-activity optimization of N-arylindole GPR52 agonists for enhanced antipsychotic efficacy: design, synthesis, and pharmacological evaluation
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GPR52 is a promising therapeutic target for schizophrenia, capable of addressing positive, negative, and cognitive symptoms simultaneously. In this study, we designed and synthesized a series of N-arylindole GPR52 agonists by optimizing the "m6" linker confi... ...
