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Compartment-specific nitric oxide signaling in mouse cardiac endothelial cells: Intra- and extracellular measurements and the impact of cryopreservation

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Nitric oxide (NO) produced by endothelial cells plays a central role in regulating vascular tone, blood flow, and inflammatory responses. Although NO freely diffuses across cell membranes, intracellular and extracellular NO-related signals are often measured i... ...