Polarity- and Sequence-Dependent Ionization of Therapeutic Antibody-siRNA Conjugates: Enabling Intact Multi-attribute Method for Comprehensive Characterization and Identity Release Assay
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Antibody-siRNA conjugates (ARCs) represent a promising approach for delivering small interfering ribonucleic acids (siRNAs) to targeted cells, tissues, or organs. The complexity of the molecules poses great analytical challenges in identifying, characterizing,... ...
