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Withanolides from Datura stramonium: two unprecedented B-ring-seco derivatives and anti-inflammatory active analogues

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UV-guided separation of the Datura stramonium L. extract led to the elucidation of thirteen previously unreported withanolides (1-13), together with nine known analogues (14-22). Compounds 1 and 2 are unprecedented withanolides featuring B-ring cleavage and be... ...