P450 engineering via structure-guided rational design achieves high C21-selectivity and bioconversion in steroid biosynthesis
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C21-hydroxylation is a crucial step in the synthesis of corticosteroids. For instance, C21-hydroxylase catalyzes the conversion of progesterone (PRO) into 11-deoxycorticosterone (DOC, the precursor of cortisol and aldosterone). Through structure-guided rationa... ...
