Design, synthesis and characterization of a novel GCP derivative as a potential 14-3-3 sigma homodimer stabilizer
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This study reports the design and characterization of a novel dimer stabilizer targeting the 14-3-3σ protein, a signaling protein with purported tumor-suppressive roles. Using an in silico design strategy based on the derivatization of GCP-Lys-OMe, a known st... ...
