Variant identification and genotyping strategy for the smg-1(r861) allele in Caenorhabditis elegans
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The C. elegans smg-1 gene encodes a PI3K-related kinase responsible for initiating the process of nonsense-mediated decay (NMD). The smg-1 ( r861 ) allele is a strong loss-of-function variant that disrupts NMD activity leading to the stabilization of transcrip... ...
