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Simultaneous quantification of chondroitin sulfate and dermatan sulfate in crude heparins using 1H NMR and independent component analysis

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Heparin, an essential anticoagulant in clinical practice, is susceptible to contamination with chondroitin sulfate (CS) and dermatan sulfate (DS). Ensuring the reliable quantification of these polysaccharides in crude heparins is critical for product safety an... ...