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Biosynthesis of ent-acu-dioxomorpholine A and its conversion to prenyl-rearranged and rare ketooxadiazepane products in heterologous host

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Diketomorpholines (DKMs) represent an intriguing class of biologically active heterocycles. To identify unusual DKM natural products, we conducted a comprehensive analysis of fungal genomes from NCBI and our laboratory databases. A non-ribosomal peptide synthe... ...