From Natural Limonoids to a Rationally Designed Derivative: Facilitating the Study of Anti-Adenocarcinoma Potential and Mechanisms Through Solubility Enhancement
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Natural limonoids, exemplified by limonin from lemon seeds, exhibit promising antitumor activity but are hindered by poor aqueous solubility, which critically limits their bioavailability and cellular engagement. To address this, a rational structure-based des... ...
