Crustacean Mab21 proteins drive tissue-specific antiviral immunity by activating IKKε outside the canonical nucleic-acid sensing paradigm
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The Mab21/cGAS protein family has diversified across metazoans to regulate development and innate immunity. In vertebrates, cGAS detects cytosolic DNA and synthesizes 2'3'-cGAMP to activate STING-TBK1-IRF signaling, while invertebrate cGAS-like receptors (cG... ...
