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Phosphatidylinositol-3-kinase/protein kinase B signaling dysregulation in steroid-induced osteonecrosis of the femoral head: A minireview of therapeutic implications

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Steroid-induced osteonecrosis of the femoral head (SIONFH) is a serious complication of glucocorticoid (GC) therapy and is characterized by progressive bone collapse, ischemia, and impaired bone regeneration. The phosphatidylinositol-3-kinase/protein kinase B ... ...