Hybrid lipoplex co-delivering siPD-L1/miR-140-5p reverses T cell exhaustion via post-transcriptional regulation for in situ photothermal vaccination
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Mild photothermal therapy (MPTT) can generate an in situ vaccine by releasing tumor-associated antigens (TAAs), yet its efficacy is often compromised by the concomitant upregulation of programmed cell death ligand 1 (PD-L1) in tumor cells, leading to T cell ex... ...
