Exploring pyrazoline-thiophene hybrids as CDK2 inhibitors: synthesis, mechanism, biological studies, and computational insights
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Pyrazoline-linked thiophenes (4a-p), a novel family of compounds, were designed and synthesized, and their anticancer potential was assessed. The most effective analogues of bis-thiophene (4n and 4o) and tris-thiophene (4p) were discovered to have sub-micromol... ...