The Disrupted Mitochondrial Quality Control Network: A Unifying Mechanism and Therapeutic Target for Chemotherapy-Induced Multi-Organ Toxicity
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Chemotherapy remains a cornerstone of systemic cancer treatment, yet dose-limiting toxicities-cardiotoxicity, neurotoxicity, and nephrotoxicity-affect 40-80% of patients, interrupt 20-30% of treatment cycles, and double long-term mortality. We propose that the... ...
