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Quantifying Oxidized Methionines with Mass Spectrometry to Map the Surface of Hamster Prion Strains Sc237 and 139H

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Sc237 and 139H are two phenotypically different prion strains of hamster (Mesocricetus auratus) adapted scrapie. Each replicates by inducing the natively expressed hamster PrPC to adopt its infectious conformation. The nine methionines in hamster PrPC can be o... ...