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Biomarkers of primary and secondary resistance to cyclin dependent kinases 4 and 6 inhibitors in metastatic estrogen receptor-positive/human epidermal growth factor receptor 2-negative breast cancer: a narrative review

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Background and objective: Cyclin dependent kinases 4 and 6 (CDK4/6) inhibitors are a class of drugs that are used in the first-line therapy of metastatic estrogen receptor (ER) positive/human epidermal growth factor receptor 2 (H... ...