Sirtuin 1 inhibits NLRP3 inflammasome activation through protein-protein interaction
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Sirtuin 1 (SIRT1) is known to suppress NLRP3 inflammasome activation via NF-κB inhibition, but its role in inflammasome assembly remains unclear. Here, using a HEK293T reconstitution system, we show that SIRT1 directly interacts and co-localizes with NLRP3 up... ...
